Panbonis®: the unique, safe, and natural source of the bioactive form of vitamin D3

  • Improves calcium and phosphorus metabolism

  • Improves eggshell quality

  • Increases the number of saleable eggs

  • Improves FCR

  • Helps to reach 500 eggs per hen housed

  • Improves fertility

  • Improves piglet vitality and litter homogeneity

  • Shortens parturition time

Panbonis® is a complementary feed that contains a standardized level of 1,25 dihydroxycholecalciferol-glycosides (1,25(OH)2D3-gly) from dried and ground Solanum glaucophyllum leaves.

1,25(OH)2D3-gly can only be absorbed after the sugar molecule is released from 1,25(OH)2D3 by specific enzymes that are present in the intestine. This gradual process ensures a slow release of the bioactive component. Once absorbed, it does not need additional activation steps like vitamin D3 or 25-hydroxycholecalciferol (25(OH)D3) do, which means that Panbonis® can directly support the animal even when specific activation enzymes in liver and kidney are limited.

  • Supports the crucial role of vitamin D3

  • 100% Natural

  • GMO-free

  • Standardized content of the active ingredient

  • Gradually absorbed from the intestine

  • Considered a complementary feed in the EU

  • High processing and storage stability

Vitamin D3 (metabolites) in animal feed

The following three vitamin D3 metabolites can be used to supplement animal feed:

  1. Vitamin D3- the most common source

  2. 25-hydroxycholecalciferol (25(OH)D3)- either produced in a chemical process or through fermentation

  3. 1,25-dihydroxycholecalciferol-glycosides (1,25(OH)2D3-gly)- an entirely natural source of the bioactive form of vitamin D3

Learn more

Some characteristics of the vitamin D3 and its metabolites, as used in animal nutrition, are summarised in Table 1.

  Vitamin D3 25(OH)D3 Panbonis®
Principal molecule Vitamin D3 25(OH)D3 1,25(OH)2D3-gly
Solubility Fat-soluble Fat-soluble Water-soluble
Enzymatic activation steps 2 steps: In liver and kidney 1 step: In kidney No activation needed: Cleavage of glycosides in the intestine

From Vitamin D3 to the active metabolite

Poultry – Vitamin D Metabolism
Ruminant – Vitamin D Metabolism
Swine – Vitamin D Metabolism

Product characteristics

  • Heat stable during feed processing (expender, pelleting and expander-pelleting)

  • Shelf life: 24 months, when stored in a dry place at room temperature

  • Particle size: 0.2mm; >90% between 0.05 – 1.6mm

  • Packaging: 20kg bags

  • Available for organic production, too


Dosage:
The general dosage is 50 - 200g of Panbonis® 10 per ton of feed, providing 0,5-2µg of 1,25(OH)2D3 -equivalents/kg of feed. Because it is supplied in addition to the usual supplementation level of vitamin D3, there is no need to adjust the premix.

Contact us to find customized information.

FAQs

  • What is the composition of Panbonis®?

    Panbonis is a standardized mixture that contains waxy-leaf nightshade meal, wheat middlings, and pregelatinized wheat starch (carrier).

  • What is the difference between Panbonis® 10 and Panbonis® 20?

    The only difference is the concentration of 1,25(OH)2D3-gly.

    Panbonis® 10: 10 ppm 1,25(OH)2D3-equivalents
    Panbonis® 20: 20 ppm 1,25(OH)2D3-equivalents

  • Can Panbonis® be used in organic feed?

    Panbonis®10 Green is suitable for organic production. Dosage and active ingredient are the same as for the conventional Panbonis®. It contains waxy-leaf nightshade meal and organic wheat middlings (carrier). Panbonis®10 Green is certified according to CH-organic.

  • How is the quality of Panbonis® controlled?

    During the production process, the content of 1,25(OH)2D3-gly, measured as 1,25(OH)2D3 equivalents, along with moisture are checked several times.

    Once every year, each final product (Panbonis® 10, Panbonis® 20, and Panbonis® 10 Green) is tested and analyzed for undesired substances, including heavy metals, mycotoxins, and others.

  • What is the legal status of Panbonis®?

    The legal status depends on the country. In the EU, Panbonis® is considered a complementary feed. In case you would like to register Panbonis® in your country, please check the legal status with the competent authorities, or contact our Registration Department.

  • What is the active component in SG?

    SG contains 1,25(OH)2D3-gly. Once the glycosides are removed by gastrointestinal enzymes, 1,25(OH)2D3 becomes free and it represents the metabolic active form of vitamin D3.

  • Do 1,25(OH)2D3-gly and/or 1,25(OH)2D3 accumulate in the body?

    No, they do not. 1,25(OH)2D3-gly is not absorbed from the intestinal tract because it is water-soluble, so any excess of 1,25(OH)2D3-gly passes through the gastrointestinal tract and is not accumulated in the body. In addition, free 1,25(OH)2D3 is rapidly degraded once it has fulfilled its task.

  • Can traces of Panbonis® be found in animal products (egg, milk, meat) or can they be transfer to offspring (e.g. via milk)?

    No, they cannot. Based on current knowledge, the active component 1,25(OH)2D3-gly cannot be transferred into animal products, which also means that it cannot be transferred to offspring.

  • Why is Panbonis® used in addition to the usual vitamin D supplements?

    The usual vitamin D supplements can meet the basic requirements for vitamin D.

    However, in case there is an increased requirement for vitamin D, Panbonis® can provide support for its function. Moreover, when the enzymes needed to activate vitamin D3 are limited e.g. in case of inflammation or mycotoxicosis, adding the direct source of the bioactive form of vitamin D3 in addition to the regular vitamin D3 supplements has direct benefits to the feed.

  • Can products from SG be mixed with minerals, vitamins, etc.?

    Yes, they can. There are no restrictions regarding the mixing partners, but due to the low recommended dosage, we suggest adding Panbonis® to a premix to ensure homogenous distribution in the feed.

  • Can phytase be combined with Panbonis®?

    Yes, it can. Panbonis® can be combined with the typically used feed enzymes such as phytase, xylanase, and carbohydrase.

  • Is Panbonis® thermally stable?

    Yes, it is. No loss of 1,25(OH)2D3-gly after pelleting (75°C) was observed during the 8-month long period. An additional short-term experiment showed no degradation of 1,25(OH)2D3-gly after a 15 min treatment at 115°C.