Scientific Loop

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Vieites, Droshgic, Souza, Vargas Junior, Nunes, Kling de Moraes, da Silva Salles Correa, Caramori Junior

The aim of this study was to assess the characteristics of the tibiotarsus of male broilers at 21 and 35 days of age. The percentages of collagenous proteins (CP), non-collagenous proteins (NCP), ash, and minerals (calcium, phosphorus, potassium and sodium), as well as weight of dried and defatted tibiotarsus in natura were determined. Download the article
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Vieites, Brusamarelo, Vieira, da Silva, Souza, da Silva Salles, Caramori, Kling Moraes

Feed supplementation with 1,25-dihydroxycholecalciferol (1,25(OH)2D3) has been studied as a means to decrease the incidence of bone abnormalities in broilers and reduce dietary inclusion of calcium and phosphorus. The objective of this research was to determine the optimal level of feed supplementation with 1,25(OH)2D3 from Solanum glaucophyllum for growing broilers … Download the article
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Schlegel, Guggisberg, Gutzwiller

Solanum glaucophyllum leaves contain high levels of glycosidically bound 1,25 dihydroxyvitamin D3, the most important vitamin D metabolite. The tolerance to this source was evaluated during six weeks with fifty weaned pigs fed increasing levels … Download the article
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Mathis, Boland, Bachmann, Toggenburg

INTRODUCTION: The safety of supplementing broiler feed with a standardised herbal extract, Solanum Glaucophyllum Standardised Leaves (SGSL) containing glycosylated 1a,25-dihydroxyvitamin D3 (1,25(OH)2D3) and standardised to contain … Download the article
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Lerchbaum and Obermayer-Pietsch

Background Vitamin D has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. There is some evidence that in addition to sex steroid hormones, the classic regulators of human reproduction, … Download the article
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Gil, Plaza-Diaz, Mesa

Background: Classically, vitamin D has been implicated in bone health by promoting calcium absorption in the gut and maintenance of serum calcium and phosphate concentrations, as well as by its action on bone growth and reorganization through the action of osteoblasts and osteoclasts cells. Download the article
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Ellestad, Payne, Marhsal, Boothby

Improvements in broiler growth performance resulting from commercial selection are associated with poor skeletal health. Vitamin D3 plays an important role in Ca and P homeostasis and is essential for bone strength. Several studies have demonstrated that feeding biologically active metabolites of D3 [25(OH)D3 and 1,25(OH)2D3] can improve bone health. Request download
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Edwards

Studies were conducted to determine the effect of dietary supplementation with cholecalciferol (D3), 1,25-dihydroxycholecalciferol [1,25-(OH)2D3], 1alpha-hydroxycholecalciferol (1alpha-OHD3), and 25-hydroxycholecalciferol (25-OHD3) on utilization of phytate P by broiler chickens. Download the article
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Edwards

These studies were conducted to determine if supplementation of a corn-soybean meal diet with 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] would increase the utilization of natural phytate phosphorus by broiler chickens. Request download
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Dobenecker, Rambeck, Weiss, Senf, Renken, Kessler, Hinrichs, Bachmann, Bühler

The multiple biological effects of vitamin D are still the object of intensive research. It is critical not only for the homeostasis of calcium, phosphorus and magnesium but also for skeletal structure, immune response and performance. Pigs are able to synthesise sufficient vitamin D on their own when having outdoor access. Request download
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Bühler, Bachmann, Rambeck

The plant Solanum glaucophyllum (SG) is known to contain 1α,25-Dihydroxycholecalciferol in a glycosidic form (1α,25(OH)2D3-Gly). Products derived from this plant can therefore be used to support the functions of Vitamin D (VD) in men and animal. Request download
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Bühler, Bachmann, Mayer, von Rosenberg, Rambeck

Introduction Modern pig farming is associated with high piglet mortality. The duration of farrowing is critical and has an impact on survival and subsequent thriving of the piglets. Since tedious labour caused by weak muscle tonus is linked to blood calcium level, it was thought that increasing Ca in the sows´ diet might improve the reproductive performance. Request download
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Bachmann, Offord-Cavin, Phothirat, Horcajada, Romeis, Mathis

Vitamin D requires two metabolic steps to become biologically active. In a first step 25-hydroxyvitamin D3 is formed, which acts as storage form. After a tightly controlled step in kidney the active metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is formed. Because kidney is the relevant metabolic organ for this conversion, 1,25(OH)2D3 needs … Request download
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Bachmann, McCormack, Whitehead

Vitamin D is essential in modern poultry production. However, the classical form cholecalciferol (VD3) may not to suffice for optimal bone health in fast growing poultry because it needs two metabolic steps to become active. Supplementation with the active form 1,25- dihydroxyvitamin D3 (1,25(OH) 2D3) has been found to be the most effective means for optimizing bone quality … Request download
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Bachmann, Autzen, Frey, Wehr, Rambeck, McCormack, Whitehead

1. Chemical characterisation of an extract of Solanum glaucophyllum (SG) leaves affirmed the predominant presence of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) glycosides. The compound 1-(ss-D-glucopyranosyl)-1alpha,25-dihydroxycholecalciferol was isolated for the first time from a natural source. 2. Vitamin D activity of the extract … Request download
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Aranow

It is now clear that vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells, and antigen-presenting cells), and these immunologic cells are all capable of synthesizing the active vitamin D metabolite, vitamin D has the capability of acting in an autocrine manner in a local immunologic milieu. Download the article
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Bühler and Bachmann, 2017: Introduction on Panbonis and effects in layers and broiler

Covering the increasing demands for eggs and poultry meat, coupled with increasing expectations from the customers for sustainability, animal welfare and health, poses a great challenge for all poultry farmers around the world. Management and nutrition are two of the key factors for good animal performance and they are often interlinked. Download the article
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Abe, Horikawa, Masumura, Sugahara, Kubota, Suda

It has been reported that the rate of cracked or soft-shelled eggs markedly increases in old laying hens. We investigated the effect of age on cholecalciferol metabolism in different age groups of laying hens. The egg production rate in hens more than 500 days old was maintained within a range of about 70% of that in young hens (230-320 days old), whereas the rate of cracked or soft-shelled eggs increased markedly with age. When kidney homogenates from the different … Request download
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Bühler and Losa, 2018, Effects of Panbonis in older laying hens; importance of Ca in eggshell production

Calcium (Ca) is the most abundant mineral in an organism and up to 95% of it can be found in bones. In birds, Ca additionally plays a crucial role in egg shell formation. Ca-metabolism in birds has to be in perfect working order, independent of whether the egg weighs 2.5kg (ostrich), 500g (kiwi bird; 15-20% of the female BW) or less than O.Sg (certain hummingbirds). Download the article
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Bühler and Whitehead, 2018: Effects of Panbonis in sows; Ca and muscle contraction

How to ensure that piglets born into large litters survive and thrive until weaning is one of the main challenges in pig production today. Although the number of piglets born has markedly increased in recent years, the number of piglets weaned could not keep up and is lagging behind. This is not only an economical loss but also raises concerns regarding animal welfare. Download the article
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Bühler and van der Klis, 2020: Ca-Metabolism and reduced activity of 1alpha-hydroxylase in older laying hens; Panbonis as a tool to support 500 eggs per hen

Keeping laying hens up to 100 weeks of age (producing 500 eggs) without moulting is no longer an utopian idea. Such long production periods require new tools to support the hen to produce high quality eggs until the end of the laying cycle. Maintaining good eggshell quality is especially crucial. Independent of egg weight, the eggshell weight and therefore the amount of calcium (Ca) deposited remains more or less constant over time. Download the article
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