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Green Power for Pig Health and Welfare
This article explores the health and performance benefits of phytogenic feed ingredients in swine production. It highlights the role of Solanum glaucophyllum and other plant-based compounds in supporting vitamin D metabolism, improving piglet vitality, and promoting resilience in weaned piglets. The publication provides data and insights on the use of plant …
Kathrin Bühler, Sabrina Autzen, Clémence Messant
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Article Poultry

EGGCELLENT - Cracking Eggshell Quality in Ageing Laying Hens

Interplay of vitamin D, calcium, and phosphorus metabolism in eggshell formation.

Herbonis Animal Health GmbH
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Abstract

1,25(OH)2D3-glycosides from Solanum glaucophyllum alter gene expression in broilers at 21 and 42 days of age

Supplementation of G-1,25(OH)2D3 alters physiological pathways connected to mineral metabolism and immunity in broilers

by Kathrin Bühler, Laura Payling, Mislav Acman, Luis Romero, Jan Dirk van der Klis
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Abstract Ruminant

The importance of colostrum during the first days of the piglet’s life

Colostrum, the ‘first milk’ produced by mammals in the first 24 to maximal 48 hours after giving birth, differs from the milk produced later during the lactation phase (mature milk). In general, colostrum has a higher protein and a lower lactose and fat content than mature milk.

International Pig Topics
Volume 38 Number 3

by Kathrin Buehler and Katia Pedrosa, Herbonis Animal Health GmbH
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Article Poultry

Activated vitamin D: Connecting parents and offspring

Good chick quality and the number of fertile settable eggs per hen housed are the main drivers in broiler breeder operations. Apart from incubation conditions, successful hatchability depends on many factors related to eggshell quality (for example strength, porosity and absence of microfractures).

by Katia Pedrosa and Kathrin Buehler, Herbonis Animal Health GmbH
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Article Poultry

Understanding the lack of 1,25(OH)2 vitamin D3 in aged laying hens

During the last decade, great progress has been made on the laying persistency of white and brown laying hens. As a result, there is an increasing number of flocks that pass the ‘500 eggs milestone’ in many countries. This milestone is better known as ‘500 eggs per hen housed without moulting’.

by Jan Dirk van der Klis and Katia Pedrosa, Herbonis Animal Health GmbH
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Article Swine

Herbal vitamin D metabolite helps the farrowing process

With the increasing prolificity of sows it becomes essential to adjust nutrition to cover the needs of modern breeds. An important nutrient is vitamin D, as it is a key factor in calcium (Ca) and phosphorus (P) metabolism. The mineral requirement of sows is very high from the third part of gestation until the end of lactation.

by Katia Pedrosa, Dr Kathrin Buehler and Dr Jan Dirk Van der Klis, Herbonis Animal Health
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Article Ruminant

Getting the balance right: the underestimated weight of dietary calcium

The macronutrient calcium (Ca) is mostly known for its crucial role in bone mineralisation and bone strength. Containing 99% of the body Ca reserves, the skeleton is the major storage site for Ca. Besides maintaining skeletal integrity, Ca is important for muscle contraction, neuronal transmission, intracellular signalling and many other functions.

by R&D and Technical Team, Herbonis Animal Health GmbH
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Scientific Article Poultry

A beat of science 004: Heat stress in laying hens

The combination of high ambient temperatures and high humidity is a well-known external stressor in livestock production. Layers are particularly sensitive to heat stress, because of daily egg and eggshell production.

Herbonis Animal Health GmbH
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Article Swine

Vitamin D3 and its metabolites in sow fertility and performance

The number of piglets born alive, litter size at birth, and the number of weaned piglets per sow per year are reproductive traits with great economic impact on the profitability of pig production. Achieving high farrowing rates throughout the sow’s life, along with litter uniformity, are great challenges in high prolific sows.

Katia Pedrosa & Kathrin Bühler, Herbonis Animal Health GmbH
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Article Poultry

Natural vitamin D3 metabolite supports bone health of laying hens
Proper skeleton calcium (Ca) stores is key to reduce bone disorders. Early sexual maturation, alongside production of the first egg at a younger age, fast increase to peak production and improved laying persistency, has increased the demand for proper skeletal Ca stores at the start of egg production. Only then can bone and shell quality be maintained …
Katia Pedrosa & Jan Dirk Van der Klis, Herbonis Animal Health GmbH
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Active vitamin D3-glycoside preserves weight gain and modulates the inflammatory response in broiler chickens challenged with lipopolysaccharide
Keeping laying hens up to 100 weeks of age (producing 500 eggs) without moulting is no longer an utopian idea. Such long production periods require new tools to support the hen to produce high quality eggs until the end of the laying cycle. Maintaining good eggshell quality is especially crucial. Independent of egg weight, the eggshell weight and therefore …
Nunes, Duarte, Campos, de Oliveira, Silva, Kreuz, Mirabile, Borges, Calderano
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Article Poultry

Solanum glaucophyllum in layer hen diets to reduce dietary phosphorus

Modern laying hens have a huge potential to produce affordable and high quality animal protein. In current practice, layers can produce over 500 eggs per hen-housed, whereas the potential of certain genetics under optimal conditions is already at least 30% higher.

by Jan Dirk van der Klis and Kathrin Buehler, Herbonis Animal Health GmbH
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Scientific Paper Poultry

Bone characteristics of broiler chickens fed diets supplemented with Solanum glaucophyllum

The aim of this study was to assess the characteristics of the tibiotarsus of male broilers at 21 and 35 days of age. The percentages of collagenous proteins (CP), non-collagenous proteins (NCP), ash, and minerals (calcium, phosphorus, potassium and sodium), as well as weight of dried and defatted tibiotarsus in natura were determined.

Vieites, Droshgic, Souza, Vargas Junior, Nunes, Kling de Moraes, da Silva Salles Correa, Caramori Junior
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Scientific Paper Poultry

1,25-dihydroxycholecalciferol from Solanum glaucophyllum supports normal growth and reduces the negative effects of calcium and phosphorus restriction on broilers’ bone tissue
Feed supplementation with 1,25-dihydroxycholecalciferol (1,25(OH)2D3) has been studied as a means to decrease the incidence of bone abnormalities in broilers and reduce dietary inclusion of calcium and phosphorus. The objective of this research was to determine the optimal level of feed supplementation with 1,25(OH)2D3 from Solanum glaucophyllum for growing …
Feed supplementation with 1,25-dihydroxycholecalciferol (1,25(OH)2D3) has been studied as a means to decrease the incidence of bone abnormalities in broilers and reduce dietary inclusion of calcium and …
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Scientific Paper Swine

Tolerance to 1,25 dihydroxyvitamin D3 glycosides from Solanum glaucophyllum by the growing pig

Solanum glaucophyllum leaves contain high levels of glycosidically bound 1,25 dihydroxyvitamin D3, the most important vitamin D metabolite. The tolerance to this source was evaluated during six weeks with fifty weaned pigs fed increasing levels …

Schlegel, Guggisberg, Gutzwiller
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Scientific Paper Poultry

Safety profile of 1,25-dihydroxyvitamin D3 of herbal origin in broiler chicken

The safety of supplementing broiler feed with a standardised herbal extract, Solanum Glaucophyllum Standardised Leaves (SGSL) containing glycosylated 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and standardised to contain …

Mathis, Boland, Bachmann, Toggenburg
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Scientific Paper Swine

Vitamin D and fertility: a systematic review

Background Vitamin D has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. There is some evidence that in addition to sex steroid hormones, the classic regulators of human reproduction, …

Lerchbaum, Obermayer-Pietsch
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Scientific Paper Poultry Ruminant Swine Aqua

Vitamin D: Classic and Novel Actions

Background: Classically, vitamin D has been implicated in bone health by promoting calcium absorption in the gut and maintenance of serum calcium and phosphate concentrations, as well as by its action on bone growth and reorganization through the action of osteoblasts and osteoclasts cells.

Gil, Plaza-Diaz, Mesa
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Abstract Poultry Ruminant Swine Aqua

Consequences of genetic selection on metabolic regulation of skeletal health in broiler chickens

Improvements in broiler growth performance resulting from commercial selection are associated with poor skeletal health. Vitamin D3 plays an important role in Ca and P homeostasis and is essential for bone strength. Several studies have demonstrated that feeding biologically active metabolites of D3 [25(OH)D3 and 1,25(OH)2D3] can improve bone health.

Ellestad, Payne, Marhsal, Boothby
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Scientific Paper Poultry

Studies on the Efficacy of Cholecalciferol and Derivatives for Stimulating Phytate Utilization in Broilers

Studies were conducted to determine the effect of dietary supplementation with cholecalciferol (D3), 1,25-dihydroxycholecalciferol [1,25-(OH)2D3], 1alpha-hydroxycholecalciferol (1α-OHD3), and 25-hydroxycholecalciferol (25-OHD3) on utilization of phytate P by broiler chickens.

Edwards
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Abstract Swine

Efficacy of orally administered Solbone®, an herbal source of metabolic active vitamin D, in piglets

The multiple biological effects of vitamin D are still the object of intensive research. It is critical not only for the homeostasis of calcium, phosphorus and magnesium but also for skeletal structure, immune response and performance. Pigs are able to synthesise sufficient vitamin D on their own when having outdoor access.

Dobenecker, Rambeck, Weiss, Senf, Renken, Kessler, Hinrichs, Bachmann, Bühler
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Abstract Poultry

Difference in time to action between a 1α,25 (OH)2D3-glycoside containing extract of Solanum glaucophyllum and Vitamin D in Japanese quails

The plant Solanum glaucophyllum (SG) is known to contain 1α,25-Dihydroxycholecalciferol in a glycosidic form (1α,25(OH)2D3-Gly). Products derived from this plant can therefore be used to support the functions of Vitamin D (VD) in men and animal.

Bühler, Bachmann, Rambeck
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Abstract Swine

Herbal vitamin D metabolite facilitates parturition in sows
Introduction Modern pig farming is associated with high piglet mortality. The duration of farrowing is critical and has an impact on survival and subsequent thriving of the piglets. Since tedious labour caused by weak muscle tonus is linked to blood calcium level, it was thought that increasing Ca in the sows´ diet might improve the reproductive performance.
Bühler, Bachmann, Mayer, von Rosenberg, Rambeck
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Scientific Paper Poultry Ruminant Swine Aqua

1,25-Dihydroxyvitamin D3-glycoside of herbal origin exhibits delayed release pharmacokinetics when compared to its synthetic counterpart

Vitamin D requires two metabolic steps to become biologically active. In a first step 25-hydroxyvitamin D3 is formed, which acts as storage form. After a tightly controlled step in kidney the active metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is formed. Because kidney is the relevant metabolic organ for this conversion, 1,25(OH)2D3 needs …

1982 - Bachmann, Offord-Cavin, Phothirat, Horcajada, Romeis, Mathis
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Scientific Paper Poultry

The effectiveness of a new standardized Solanum glaucophyllum preparation for optimizing bone quality in broilers.
Vitamin D is essential in modern poultry production. However, the classical form cholecalciferol (VD3) may not to suffice for optimal bone health in fast growing poultry because it needs two metabolic steps to become active. Supplementation with the active form 1,25- dihydroxyvitamin D3 (1,25(OH) 2D3) has been found to be the most effective means for …
Bachmann, McCormack, Whitehead
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Scientific Paper Poultry

The efficacy of a standardised product from dried leaves of Solanum glaucophyllum as source of 1,25-dihydroxycholecalciferol for poultry

1. Chemical characterisation of an extract of Solanum glaucophyllum (SG) leaves affirmed the predominant presence of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) glycosides. The compound 1-(β-D-glucopyranosyl)-1α,25-dihydroxycholecalciferol was isolated for the first time from a natural source. 2. Vitamin D activity of the extract …

Bachmann, Autzen, Frey, Wehr, Rambeck, McCormack, Whitehead
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Scientific Paper Poultry Ruminant Swine Aqua

Vitamin D and the Immune System
It is now clear that vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells, and antigen-presenting cells), and these immunologic cells are all capable of synthesizing the active vitamin D metabolite, vitamin D has the capability of acting in …
Aranow
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The advantages of waxy-leaf nightshade for poultry performance

Covering the increasing demands for eggs and poultry meat, coupled with increasing expectations from the customers for sustainability, animal welfare and health, poses a great challenge for all poultry farmers around the world. Management and nutrition are two of the key factors for good animal performance and they are often interlinked.

Bühler, Bachmann
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Article Poultry

Vitamin D3 metabolite 1,25(OH)2D3 and immune response in broilers

As antibiotic-free broiler production, often even including ionophore coccidiostats, is becoming more common, the immunocompetence of birds becomes increasingly important. One way to achieve this is to modulate and support the immune system to increase disease resistance of the animals.

Kathrin Bühler & Katia Pedrosa, Herbonis Animal Health GmbH
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