• supports Ca metabolism
  • reduces the risk for hypocalcemia in dairy cows
  • stabilizes serum calcium concentration during the transition period
  • reduces the incidence of milk fever
  • is gradually absorbed from the rumen
  • only one bolus application required

SOLIBOL®+ is a bolus for the prevention of hypocalcemia in dairy cows. It contains Panbovine®, a standardized natural source of the bioactive form of vitamin D to support calcium metabolism.


  • 100% natural
  • GMO-free
  • Standardized content of the active ingredient
  • Gradually released in the rumen
  • One time application
  • Small bolus (ca. 75 g)

Vitamin D in the prevention of hypocalcemia in dairy cows.

Vitamin D3 is a key player in calcium metabolism. It is produced with the help of UV-B in the skin or ingested as such via the diet. In the liver, vitamin D3 is converted to its circulating form, 25-hydroxyvitamin D3. To become metabolically active, a second conversion step in the kidneys to 1,25-dihydroxycholecalciferol (1,25(OH)2D3) is necessary.
In the peripartum period, hypocalcemia in dairy cows is caused by the sudden increase in the excretion of calcium via the milk, while the vitamin D metabolism is not yet upregulated. Therefore, some cows cannot adequately increase intestinal calcium absorption to maintain blood calcium homeostasis. 1,25(OH)2D3 supports the sudden metabolic adaptations around calving id to maintain blood calcium homeostasis. SOLIBOL®+ releases over a period of 10 days the natural source of the bioactive form of vitamin D thanks to the unique ingredient Panbovine®. Panbovine® contains 1,25-dihydroxycholecalciferol (1,25(OH)2D3) bound to sugar molecules (glycoside) from the plant Solanum glaucophyllum. This ensures a sufficient calcium supplementation of the cow during the critical period at onset of milk production.

Special benefits of SOLIBOL®+

Figure 1. Serum calcium content in blood of multiparous dairy cows after having been given a prototype of SOLIBOL®+ approximately 5 days before the expected calving date.

SOLIBOL®+ applied approximately 5 days before the expected calving date prevented the dip in serum calcium content immediately after calving (Figure 1). Herbonis has shown that SOLIBOL®+ was effective to prevent hypocalcemia as in trials so far none of the cows that were supplied with a bolus developed hypocalcemia.

In a field trial with SOLIBOL®+ not only serum calcium contents but also production performance in the first 15 days after calving was assessed. Cows receiving SOLIBOL®+ had a daily milk yield which was more than 2 liters higher than in the control animals. In addition, SOLIBOL®+ increased dry matter intake.

  Control SOLIBOL®+
Milk yield (L/cow/day) 25.7 27.9
Feed intake (kg DM/cow/day) 18.3 19.1
Milk/Feed intake (L/kg DM) 1.40 1.46

How to use SOLIBOL®+

Shelf life: 12 months when stored in a dry place at room temperature.

Packaging: 12 bolus per box

Dosage: Bolus disintegrates over 10 days. Apply bolus ideally 2 to 5 days before expected calving. If the cow has not calved earliest 10 days after bolus application, check for signs of a live calf and apply a second bolus. If the cow calves within half a day after bolus application, no additional bolus is required.

Remark: Cows with clinical signs of milk fever can be treated as usual. Inform veterinarian about the bolus.

Caution: Do not simultaneously use vitamin D injections. Vitamin D injections should be applied earliest 10 days after bolus application.

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